Mannan-binding lectin serine protease

Function Mannan-binding lectin serine protease (MASP) are proteases associated with mannan-binding lectin (MLB). The lectin pathway of complement is part of the innate immunity. The pathway activation occurs via recognition of pathogens by MBL followed by activation of MASP leading to activation of the complement system. Relevance MASP-1 and MASP-2 contribute to clot formation and may represent an important link between inflammation and thrombosis. MASP levels may be altered in vascular diseases. Structural highlights . MASP-1, MASP-2 and MASP-3 are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid, .

spinqualitylabelsall models Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code 3tvj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of mannan-binding lectin serine protease3D structures of mannan-binding lectin serine protease

Updated on 11-July-2024

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• Mannan-binding serine protease 1
  • 4aqb – hMASP-1 - human
    
  • 4igd – hMASP-1 catalytic domain (mutant)
    
  • 4djz – hMASP-1 chain A sushi domain, chain B catalytic domain + SGPI-2
    
  • 3gov – hMASP-1 chain A sushi domain, chain B catalytic domain
    
  • 3pob – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat
    
  • 3poe, 3pof, 3pog, 3poi, 3poj – rMASP-1 CUB2 domain
    
  • 5ckq – rMASP-1 CUB1-EGF-CUB2 domain
    
• Mannan-binding serine protease 2
  • 5jpm – hMASP-2 (mutant) + complement C4-A
    
  • 3tvj – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2
    
  • 1q3x – hMASP-2 catalytic domain
    
  • 1zjk – hMASP-2 catalytic domain (mutant)
    
  • 1nt0, 5cis, 5ckm, 5ckn – hMASP-2 CUB1-EGF-CUB2 domain
    
• Mannan-binding serine protease 3
  • 4kkd – hMASP-3 (mutant)
    
  • 3dem – hMASP-3 CUB1-EGF-CUB2 domain
    
  • 4iw4 – MASP-3 catalytic domain + ecotin – Escherichia coli