Mannan-binding lectin serine protease: Difference between revisions
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<StructureSection load='3tvj' size='340' side='right' caption=' | <StructureSection load='3tvj' size='340' side='right' caption='Human MAPS-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code [[3tvj]])' scene=''> | ||
== Function == | == Function == | ||
'''Mannan-binding lectin serine protease''' (MASP) are proteases associated with mannan-binding lectin (MLB). The lectin pathway of complement is part of the innate immunity. The pathway activation occurs via recognition of pathogens by MBL followed by activation of MASP leading to activation of the complement system<ref>PMID:22670777</ref>. | '''Mannan-binding lectin serine protease''' (MASP) are proteases associated with mannan-binding lectin (MLB). The lectin pathway of complement is part of the innate immunity. The pathway activation occurs via recognition of pathogens by MBL followed by activation of MASP leading to activation of the complement system<ref>PMID:22670777</ref>. | ||
== Relevance == | == Relevance == | ||
MASP-1 and MASP-2 contribute to clot formation and may represent an important link between inflammation and thrombosis. MASP levels may be altered in vascular diseases<ref>PMID:23607747</ref>. | |||
== Structural highlights == | == Structural highlights == | ||