5t2r: Difference between revisions

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'''Unreleased structure'''


The entry 5t2r is ON HOLD until Paper Publication
==Unliganded Human HVEM at 2.1A in P 21 21 21==
 
<StructureSection load='5t2r' size='340' side='right' caption='[[5t2r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5t2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T2R FirstGlance]. <br>
Description:  
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t2q|5t2q]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t2r OCA], [http://pdbe.org/5t2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t2r RCSB], [http://www.ebi.ac.uk/pdbsum/5t2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t2r ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Nemcovicova, I]]
[[Category: Zajonc, D M]]
[[Category: Herpesvirus entry mediator]]
[[Category: Hvem]]
[[Category: Immune system]]
[[Category: Tnfrsf14]]

Revision as of 08:43, 24 October 2018

Unliganded Human HVEM at 2.1A in P 21 21 21Unliganded Human HVEM at 2.1A in P 21 21 21

Structural highlights

5t2r is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TNR14_HUMAN] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.[1]

References

  1. ↑ Montgomery RI, Warner MS, Lum BJ, Spear PG. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell. 1996 Nov 1;87(3):427-36. PMID:8898196

5t2r, resolution 2.10Å

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