Talin: Difference between revisions

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{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}


[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.  
[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.  


== 3D Structures of Talin ==
== 3D Structures of Talin ==
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* Talin subdomains  
* Talin subdomains  


**[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
**[[2x0c]]  – mTal rod residues 1359-1659 – mouse<br />
**[[2kma]] – mTal F0F1 – NMR<br />
**[[5ic0]], [[2kbb]] – mTal residues 1357-1822<br />
**[[2kc1]] - mTal F0 – NMR<br />
**[[5ic1]] – mTal residues 1357-1822 (mutant)<br />
**[[2kc2]] - mTal F1 – NMR<br />
**[[3dyj]] - mTal residues 1974-2293<br />
**[[2hrj]] - cTal F2 – NMR <br />
**[[1sj7]], [[1sj8]] - mTal residues 482-655<br />
**[[1mix]] – cTal F2F3<br />
**[[2kma]] – mTal F1F2 residues 1-202 – NMR<br />
**[[4f7g]] - mTal F2F3 + rod segment domain<br />
**[[2kc1]] - mTal F1 residues 1-85 – NMR<br />
**[[2kgx]] – mTal F3+mTal fragment – NMR<br />
**[[2kc2]] - mTal F2 residues 86-202 – NMR<br />
**[[3ivf]] – mTal FERM domain<br />
**[[3ivf]] – mTal FERM domain F1F2F3 residues 1-400<br />
**[[2l7n]] – mTal B – NMR<br />
**[[2qdq]] – mTal dimerization domain residues 2494-2541<br />
**[[2l10]] – mTal C - NMR<br />
**[[2hrj]] - cTal F2 – chicken - NMR <br />
**[[2lqg]] - mTal R4 helix – NMR<br />
**[[1mix]] – cTal F2F3 residues 196-400<br />
**[[4w8p]] - mTal R7-8 + RIAM <br />
**[[4f7g]] - mTal F2F3 residues 206-405 + rod segment domain residues 1654-1847<br />
**[[2mwn]] – hTal1 + RIAM – human - NMR<br />
**[[2kgx]]– mTal F3 residues 334-402 +mTal fragment residues 1655-1822– NMR<br />
**[[2l10]] – mTal residues 1206-1357 – NMR<br />
**[[2l7n]] – mTal residues 1046-1207 – NMR<br />
**[[2lqg]] - mTal R4 helix residues 913-1044 – NMR<br />
**[[4w8p]] - mTal R7-8 residues 1359-1659 + RIAM <br />
**[[5fzt]] - mTal R7-8 residues 1359-1659 + Rho GTPase activating protein 7 peptide <br />
**[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR<br />


* Talin integrin-binding sites  
* Talin integrin-binding sites  
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**[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
**[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
**[[3g9w]] – mTal2 F2F3+integrin tail<br />
**[[3g9w]] – mTal2 F2F3+integrin tail<br />
**[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
**[[1miz]], [[1mk7]], [[1mk9]] - cTal F2F3 residues 200-400 +integrin tail<br />
**[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
**[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
**[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
**[[3fyq]] – Tal rod IBS2 residues 1981-2168 – ''Drosophila melanogaster''


* Talin vinculin-binding sites  
* Talin vinculin-binding sites  


**[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
**[[2kvp]], [[2b0h]] – mTal VBS3 residues 2300-2482 – NMR<br />
**[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
**[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
**[[1u6h]] - cTal VBS2+ vinculin head<br />
**[[1u6h]] - cTal VBS2 residues 849-879 + vinculin head<br />
**[[1t01]] - cTal VBS1+ vinculin head<br />
**[[1t01]] - meal VBS1 residues 605-628 + vinculin head<br />
**[[1syq]] - hTal VBS1+ vinculin head <br />
**[[1syq]] - hTal VBS1+ vinculin head <br />
**[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br />
**[[1rkc]] - cTal VBS3+ vinculin head<br />
**[[3s90]] - mTal VBS3 residues 1512-1546 + vinculin head<br />
**[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
**[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
**[[4dj9]] – hTal VBS50 + vinculin head
**[[4dj9]] – hTal VBS50 + vinculin head

Revision as of 09:57, 7 September 2016

Template:STRUCTURE 2x0c

Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

3D Structures of Talin3D Structures of Talin

Updated on 07-September-2016

ReferencesReferences

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
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