NAD kinase: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='1z0u' size='340' side='right' caption='NAD kinase complex with NADP and sulfate (PDB code [[1z0u]]' scene=''> | <StructureSection load='1z0u' size='340' side='right' caption='NAD kinase complex with NADP and sulfate (PDB code [[1z0u]]' scene=''> | ||
== Function == | == Function == | ||
'''NAD kinase''' (NADK) catalyzes the conversion of ATP and [[NAD]] to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism<ref>PMID:23212377</ref>. See [[NAD]] and [[NAD(P)H]]. | |||
== Structural highlights == | == Structural highlights == | ||
NADP is bound to NADK in a cleft between the N and C-terminal domains in the dimer interface<ref>PMID:16242716</ref>. | |||
</StructureSection> | </StructureSection> |