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==Solution structure of first LIM domain of Enigma-like PDZ and LIM domains protein== | ==Solution structure of first LIM domain of Enigma-like PDZ and LIM domains protein== | ||
<StructureSection load='2dar' size='340' side='right' caption='[[2dar]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2dar' size='340' side='right' caption='[[2dar]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dar OCA], [http://pdbe.org/2dar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dar RCSB], [http://www.ebi.ac.uk/pdbsum/2dar PDBsum], [http://www.topsan.org/Proteins/RSGI/2dar TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dar OCA], [http://pdbe.org/2dar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dar RCSB], [http://www.ebi.ac.uk/pdbsum/2dar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dar ProSAT], [http://www.topsan.org/Proteins/RSGI/2dar TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dar_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dar_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Revision as of 09:30, 30 May 2018
Solution structure of first LIM domain of Enigma-like PDZ and LIM domains proteinSolution structure of first LIM domain of Enigma-like PDZ and LIM domains protein
Structural highlights
Function[PDLI5_HUMAN] May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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