Complexin: Difference between revisions
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<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''> | <StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene=''> | ||
== Function == | |||
'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref> | |||
== Structural highlights == | |||
CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of complexin== | ==3D structures of complexin== | ||