Adapter molecule crk: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
== Structural highlights == | == Structural highlights == | ||
Crk domains include several SH2 and SH3 domains. | Crk domains include several N-terminal SH2 and C-terminal SH3 domains. | ||
==3D structures of adpter molecule crk== | ==3D structures of adpter molecule crk== | ||
Revision as of 13:34, 27 October 2015
<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (grey) complex with proline-rich peptide (green) (PDB entry 1cka)' scene=>
FunctionFunction
Adapter molecule crk (Crk) (CT10 Regulatior of Kinase) or p38 is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.
Structural highlightsStructural highlights
Crk domains include several N-terminal SH2 and C-terminal SH3 domains.
3D structures of adpter molecule crk3D structures of adpter molecule crk
1m30, 1m3a, 1m3b, 1m3c – mCrk N terminal SH3 (mutant) – mouse - NMR
2ggr – mCrk C terminal SH3 - NMR
2l3p, 2l3q, 2l3s – Crk residues 220-297 – chicken – NMR
1cka, 1ckb – mCrk N terminal SH3 + proline-rich peptide
1b07 – mCrk N terminal SH3 + SH3 peptoid inhibitor
1ju5 – hCrk SH2 + phosphopeptide + Abl SH3 - human