Adapter molecule crk

Function

Adapter molecule crk (Crk) (CT10 Regulatior of Kinase) or p38 is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.^[1] See also SRC and Oncogenes & Tumor Suppressor Genes.

Structural highlights

Crk domains include several N-terminal SH2 and C-terminal SH3 domains. (1cka)^[2] is shown.

3D structures of adapter molecule crk

Adapter molecule crk 3D structures

Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry 1cka)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608
↑ Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608

[2] Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

[1]

[2]