Stepler sandbox STAT3: Difference between revisions
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==STAT3== | ==STAT3== | ||
<StructureSection load='1bg1' size='340' side='right' caption='STAT3 Interacting with DNA' scene=''> | <StructureSection load='1bg1' size='340' side='right' caption='STAT3 Interacting with DNA' scene=''> | ||
STAT3 (Signal Transducer and Activator of Transcription 3) is one of seven of a family of homologous STAT proteins that differentially regulate gene expression. STAT 3 is important in both the development of embryos and many functions in adult organisms | STAT3 (Signal Transducer and Activator of Transcription 3) is one of seven of a family of homologous STAT proteins that differentially regulate gene expression. STAT 3 is important in both the development of embryos and many functions in adult organisms. <ref>PMID:11050435</ref> | ||
== Structure == | == Structure == | ||
The STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. <ref>PMID:9671298</ref> | The STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. <ref>PMID:9671298</ref> There is a <scene name='71/714950/Important_c-terminal_y_residue/1'>Y residue</scene> at the C-terminal that plays a large role in transcriptional activation during regulatory events. | ||
== Regulation == | == Regulation == | ||
== DNA-Protein Interactions == | == DNA-Protein Interactions == | ||
The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of the DNA | The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of the DNA. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:20, 13 October 2015
STAT3STAT3
STAT3 (Signal Transducer and Activator of Transcription 3) is one of seven of a family of homologous STAT proteins that differentially regulate gene expression. STAT 3 is important in both the development of embryos and many functions in adult organisms. [1] StructureThe STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. [2] There is a at the C-terminal that plays a large role in transcriptional activation during regulatory events. RegulationDNA-Protein InteractionsThe by binding to the major groove of the DNA.
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ReferencesReferences
- ↑ Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502. PMID:11050435
- ↑ Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 doi:10.1038/28101