WD repeat-containing protein: Difference between revisions
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<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey | <StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey) complex with histone H3 peptide (green) (PDB code [[2h9m]])'> | ||
== Function == | == Function == | ||
'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>. WDR5 forms a beta propeller structure. | |||
== Disease == | == Disease == | ||
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>. | |||
== Relevance == | == Relevance == | ||
Revision as of 11:40, 14 December 2016
FunctionWD-repeat protein 5 (WDR5) contains 7 WD repeats. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL)[1]. WDR5 forms a beta propeller structure. DiseaseMutant WDR is involved in triple-A syndrome[2]. RelevanceStructural highlights |
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3D Structures of WD-repeat protein 53D Structures of WD-repeat protein 5
Updated on 14-December-2016
2gnq, 2h68, 2h14, 2h9l – hWDR5 – human
3mxx, 3n0d, 3n0e – hWDR5 (mutant)
3smr, 3ur4, 4ia9, 4qqe, 4ql1 – hWDR5 + piperazine derivative
2cnx, 2co0, 2h6k, 2h6n, 2h6q, 2h13, 2h9m, 2h9n, 2h9p, 2g99, 2g9a, 2o9k, 3psl, 4a7j – hWDR5 + histone H3 peptide
3eg6, 3emh – hWDR5 + MLL1 peptide
4gm3, 4gm8, 4gm9, 4gmb – hWDR5 + peptide inhibitor
2xl2, 2xl3 – hWDR5 + retinoblastoma-binding protein 5 peptide
4o45 – hWDR5 + influenza NS1 C-terminal
4cy1 – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides
4cy2 – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide
4y7r – hWDR5 + Myc MbIIIb peptide
3uvk, 3uvl, 3uvm, 3uvn, 3uvo, 4erq, 4ery, 4es0, 4esg, 4ewr – hWDR5 + MLL peptide
4erz – hWDR5 + MLL4
3p4f – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide
ReferencesReferences
- ↑ Gan Q, Thiebaud P, Theze N, Jin L, Xu G, Grant P, Owens GK. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011 Jun 17;286(24):21853-64. doi: 10.1074/jbc.M111.233098. Epub, 2011 Apr 28. PMID:21531708 doi:http://dx.doi.org/10.1074/jbc.M111.233098
- ↑ Tullio-Pelet A, Salomon R, Hadj-Rabia S, Mugnier C, de Laet MH, Chaouachi B, Bakiri F, Brottier P, Cattolico L, Penet C, Begeot M, Naville D, Nicolino M, Chaussain JL, Weissenbach J, Munnich A, Lyonnet S. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3):332-5. PMID:11062474 doi:http://dx.doi.org/10.1038/81642