Undecaprenyl pyrophosphate synthase: Difference between revisions
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== Function == | == Function == | ||
'''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. | |||
'''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Bisphosphonate drugs are UPP inhibitors. | |||
== Relevance == | == Relevance == | ||
UPP inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The active site of UPP contains an octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate<ref>PMID:15788389</ref>. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 14:05, 5 December 2016
FunctionUndecaprenyl pyrophosphate synthase (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall[1]. Bisphosphonate drugs are UPP inhibitors. RelevanceUPP inhibitors are investigated as potential antibacterials[2]. Structural highlightsThe active site of UPP contains an octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate[3]. |
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3D structures of undecaprenyl pyrophosphate synthase3D structures of undecaprenyl pyrophosphate synthase
Updated on 05-December-2016
ReferencesReferences
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
- ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200