2lum: Difference between revisions
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<StructureSection load='2lum' size='340' side='right' caption='[[2lum]], [[NMR_Ensembles_of_Models | 60 NMR models]]' scene=''> | <StructureSection load='2lum' size='340' side='right' caption='[[2lum]], [[NMR_Ensembles_of_Models | 60 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2lum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUM FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oed|2oed]], [[1p7f|1p7f]], [[1p7e|1p7e]], [[1igd|1igd]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2oed|2oed]], [[1p7f|1p7f]], [[1p7e|1p7e]], [[1igd|1igd]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lum RCSB], [http://www.ebi.ac.uk/pdbsum/2lum PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lum OCA], [http://pdbe.org/2lum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lum RCSB], [http://www.ebi.ac.uk/pdbsum/2lum PDBsum]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2lum" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Strsg]] | ||
[[Category: Guntert, P]] | [[Category: Guntert, P]] | ||
[[Category: Kazemi, S]] | [[Category: Kazemi, S]] | ||
Revision as of 13:54, 10 September 2015
Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)
Structural highlights
Publication Abstract from PubMedProteins are inherently dynamic systems whose motions cover large ranges in both magnitude and timescale. Because of the omnipresence of motion, it is likely that dynamics have important roles in the function of biomolecules. For detailed understanding of a protein's function, the three-dimensional structure and description of its dynamics are therefore required. Structure determination methods are well established, and NMR-relaxation phenomena provide insights into local molecular dynamics; moreover, recently several attempts have been made to detect concerted motion. Here, we present an ensemble-based structure-determination protocol using ensemble-averaged distance restraints obtained from exact NOE rates. Application to the model protein GB3 establishes an ensemble of structures that reveals correlated motion across the beta-sheet, concerted motion between the backbone and side chains localized in the structure core, and a lack of concerted conformational exchange between the beta-sheet and the alpha-helix. Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs.,Vogeli B, Kazemi S, Guntert P, Riek R Nat Struct Mol Biol. 2012 Sep 2. doi: 10.1038/nsmb.2355. PMID:22940676[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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