2ck5: Difference between revisions

Revision as of 01:00, 11 September 2015

SOLUTION STRUCTURE OF DELTA 1-7 AOSK1SOLUTION STRUCTURE OF DELTA 1-7 AOSK1

Structural highlights

2ck5 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1sco, 2ck4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]^[1]

References

↑ Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. PMID:15588251 doi:http://dx.doi.org/BJ20041379

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OCA

[1] Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. PMID:15588251 doi:http://dx.doi.org/BJ20041379

[1]

@@ Line 4: / Line 4: @@
 <table><tr><td colspan='2'>[[2ck5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CK5 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sco|1sco]], [[2ck4|2ck4]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck5 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [http://pdbe.org/2ck5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ck5 PDBsum]</span></td></tr>
 </table>
 == Function ==

2ck5: Difference between revisions

Revision as of 01:00, 11 September 2015

SOLUTION STRUCTURE OF DELTA 1-7 AOSK1SOLUTION STRUCTURE OF DELTA 1-7 AOSK1

Structural highlights

Function

See Also

References

Contents

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2ck5: Difference between revisions

Revision as of 01:00, 11 September 2015

SOLUTION STRUCTURE OF DELTA 1-7 AOSK1SOLUTION STRUCTURE OF DELTA 1-7 AOSK1

Structural highlights

Function

See Also

References

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