3vg6: Difference between revisions
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==Barium derivative of human LFABP== | ==Barium derivative of human LFABP== | ||
<StructureSection load='3vg6' size='340' side='right' caption='[[3vg6]], [[Resolution|resolution]] 2.22Å' scene=''> | <StructureSection load='3vg6' size='340' side='right' caption='[[3vg6]], [[Resolution|resolution]] 2.22Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3vg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3vg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VG6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stk|3stk]], [[3stm|3stm]], [[3b2h|3b2h]], [[3b2i|3b2i]], [[3b2j|3b2j]], [[3b2k|3b2k]], [[3b2l|3b2l]], [[3vg2|3vg2]], [[3vg3|3vg3]], [[3vg4|3vg4]], [[3vg5|3vg5]], [[3vg7|3vg7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stk|3stk]], [[3stm|3stm]], [[3b2h|3b2h]], [[3b2i|3b2i]], [[3b2j|3b2j]], [[3b2k|3b2k]], [[3b2l|3b2l]], [[3vg2|3vg2]], [[3vg3|3vg3]], [[3vg4|3vg4]], [[3vg5|3vg5]], [[3vg7|3vg7]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vg6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vg6 OCA], [http://pdbe.org/3vg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3vg6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vg6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3vg6" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Sharma, A]] | [[Category: Sharma, A]] | ||
[[Category: Yogavel, M]] | [[Category: Yogavel, M]] | ||
Revision as of 02:28, 5 August 2016
Barium derivative of human LFABPBarium derivative of human LFABP
Structural highlights
Function[FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Publication Abstract from PubMedWe report the use of anionic (I(-)), cationic (Ba(2+), Cd(2+)) and ionic mixtures (I(-) plus Ba(2+)) for derivatizing liver fatty acid binding protein (LFABP) crystals. Use of cationic and anionic salts in phasing experiments revealed distinct non-overlapping sites for these ions, suggesting exclusive binding regions on LFABP. Interestingly, cations of identical charge and valency (like Ba(2+) and Cd(2+)) bound to distinct pockets on the protein surface. Furthermore, a mixture of salts containing both I(-) and Ba(2+) was very useful in phasing experiments as these oppositely charged ions bound to different regions of LFABP. Our data therefore suggest that cationic and anionic salt mixtures like BaCl(2) with NH(4)I or salts like CdI, BaI where each ion has a significant anomalous signal for a given X-ray wavelength may be valuable reagents for phasing during structure determination. Utility of anion and cation combinations for phasing of protein structures.,Sharma A, Yogavel M, Sharma A J Struct Funct Genomics. 2012 May 6. PMID:22562242[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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