Plasmepsin: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Histo-Aspartic Protease | |||
[[3fns]], [[3qvc]] – PfHAP - ''Plasmodium falciparum''<br /> | **[[3fns]], [[3qvc]] – PfHAP - ''Plasmodium falciparum''<br /> | ||
[[3fnt]] – PfHAP + pepstatin<br /> | **[[3fnt]] – PfHAP + pepstatin<br /> | ||
[[3fnu]], [[3qvi]] – PfHAP + inhibitor<br /> | **[[3fnu]], [[3qvi]] – PfHAP + inhibitor<br /> | ||
*Plasmepsin I | |||
[[3qrv]] – PfPlm I residues 117-457<br /> | **[[3qrv]] – PfPlm I residues 117-457<br /> | ||
[[3qs1]] - PfPlm I residues 117-457 + inhibitor | **[[3qs1]] - PfPlm I residues 117-457 + inhibitor | ||
*Plasmepsin II | |||
[[1lf4]] – PfPlm II<br /> | **[[1lf4]] – PfPlm II<br /> | ||
[[3f9q]] – PfPlm II (mutant)<br /> | **[[3f9q]] – PfPlm II (mutant)<br /> | ||
[[2r9b]] – PfPlm II + peptide inhibitor<br /> | **[[2r9b]] – PfPlm II + peptide inhibitor<br /> | ||
[[1w6h]], [[2bju]], [[1lf2]], [[1lf3]], [[1lee]], [[2igx]], [[2igy]] – PfPlm II + inhibitor<br /> | **[[1w6h]], [[2bju]], [[1lf2]], [[1lf3]], [[1lee]], [[2igx]], [[2igy]] – PfPlm II + inhibitor<br /> | ||
[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br /> | **[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br /> | ||
[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br /> | **[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br /> | ||
*Proplasmepsin II | |||
[[1pfz]] - PfProPlm II<br /> | **[[1pfz]] - PfProPlm II<br /> | ||
[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br /> | **[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br /> | ||
[[1qs8]] - PvPlm + pepstatin derivative<br /> | **[[1qs8]] - PvPlm + pepstatin derivative<br /> | ||
*Plasmepsin IV | |||
**[[2anl]] – Plm IV + statine derivative – ''Plasmodium malariae''<br /> | |||
**[[1ls5]] - PfPlm IV + pepstatin derivative<br /> | |||
}} | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:23, 3 December 2014
Template:STRUCTURE 3fns Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive.
3D structures of plasmepsin3D structures of plasmepsin
Updated on 03-December-2014