Fibroblast growth factor: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*FGF1 | |||
[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR <br /> | **[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR <br /> | ||
[[1afc]] – bFGF1 + HS – bovine<br /> | **[[1afc]] – bFGF1 + HS – bovine<br /> | ||
[[1bar]] – bFGF1 <br /> | **[[1bar]] – bFGF1 <br /> | ||
[[2j3p]] – rFGF1 - rat<br /> | **[[2j3p]] – rFGF1 - rat<br /> | ||
[[3hal]] – FGF1 - rabbit <br /> | **[[3hal]] – FGF1 - rabbit <br /> | ||
[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br /> | **[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br /> | ||
[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]] – hFGF1 (mutant) <br /> | **[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]] – hFGF1 (mutant) <br /> | ||
[[1dzd]], [[2rq9]] – hFGF1 - NMR <br /> | **[[1dzd]], [[2rq9]] – hFGF1 - NMR <br /> | ||
[[1dzc]] – hFGF1 (mutant) - NMR <br /> | **[[1dzc]] – hFGF1 (mutant) - NMR <br /> | ||
''FGF1 complex with small molecule'' | *''FGF1 complex with small molecule'' | ||
[[1axm]], [[2axm]] – hFGF1 + HS <br /> | **[[1axm]], [[2axm]] – hFGF1 + HS <br /> | ||
[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide <br /> | **[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide <br /> | ||
[[2uus]] – rFGF1 + HS <br /> | **[[2uus]] – rFGF1 + HS <br /> | ||
[[2erm]] – hFGF1 + HS - NMR<br /> | **[[2erm]] – hFGF1 + HS - NMR<br /> | ||
[[1rml]] – hFGF1 + naphthalene trisulphonate - NMR <br /> | **[[1rml]] – hFGF1 + naphthalene trisulphonate - NMR <br /> | ||
[[1hkn]] – hFGF1 + naphthalene trisulphonate <br /> | **[[1hkn]] – hFGF1 + naphthalene trisulphonate <br /> | ||
[[2k8r]] – hFGF1 + anti-angiogenic drug - NMR<br /> | **[[2k8r]] – hFGF1 + anti-angiogenic drug - NMR<br /> | ||
[[3k1x]] – hFGF1 + vasoprotectant drug <br /> | **[[3k1x]] – hFGF1 + vasoprotectant drug <br /> | ||
[[3jut]] – hFGF1 + inhibitor <br /> | **[[3jut]] – hFGF1 + inhibitor <br /> | ||
[[2ki4]], [[2ki6]] – hFGF1 + S100-A13<br /> | **[[2ki4]], [[2ki6]] – hFGF1 + S100-A13<br /> | ||
''FGF1 complex with FGF receptor'' | *''FGF1 complex with FGF receptor'' | ||
[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br /> | **[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br /> | ||
[[3oj2]], [[3ojm]], [[1djs]] – hFGF1 + hFGFR2 (mutant) <br /> | **[[3oj2]], [[3ojm]], [[1djs]] – hFGF1 + hFGFR2 (mutant) <br /> | ||
[[1evt]] – hFGF1 + hFGFR1 <br /> | **[[1evt]] – hFGF1 + hFGFR1 <br /> | ||
[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br /> | **[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br /> | ||
[[1ry7]] – hFGF1 + hFGFR3<br /> | **[[1ry7]] – hFGF1 + hFGFR3<br /> | ||
[[3cu1]] – hFGF1 + hFGFR2<br /> | **[[3cu1]] – hFGF1 + hFGFR2<br /> | ||
*FGF2 | |||
[[2fgf]] – hFGF2 precursor <br /> | **[[2fgf]] – hFGF2 precursor <br /> | ||
[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[2bfh]], [[1bff]] – hFGF2 <br /> | **[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[2bfh]], [[1bff]] – hFGF2 <br /> | ||
[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR <br /> | **[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR <br /> | ||
[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR <br /> | **[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR <br /> | ||
[[1bfb]], [[1bfc]] – hFGF2 + heparin <br /> | **[[1bfb]], [[1bfc]] – hFGF2 + heparin <br /> | ||
[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br /> | **[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br /> | ||
[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br /> | **[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br /> | ||
[[1ev2]] - hFGF2 (mutant) + hFGFR2 <br /> | **[[1ev2]] - hFGF2 (mutant) + hFGFR2 <br /> | ||
[[2m49]] - hFGF2 (mutant) + S100-B <br /> | **[[2m49]] - hFGF2 (mutant) + S100-B <br /> | ||
*FGF4 | |||
[[1ijt]] – hFGF4 b-trefoil domain <br /> | **[[1ijt]] – hFGF4 b-trefoil domain <br /> | ||
*FGF7 | |||
[[1qqk]] – rFGF7 <br /> | **[[1qqk]] – rFGF7 <br /> | ||
[[1qql]] – rFGF7/hFGF1 <br /> | **[[1qql]] – rFGF7/hFGF1 <br /> | ||
*FGF8 | |||
[[2fdb]] – hFGF8b + hFGFR2 <br /> | **[[2fdb]] – hFGF8b + hFGFR2 <br /> | ||
*FGF9 | |||
[[1g82]], [[1ihk]] – hFGF9 <br /> | **[[1g82]], [[1ihk]] – hFGF9 <br /> | ||
*FGF10 | |||
[[1nun]] – hFGF10 + hFGFR2 <br /> | **[[1nun]] – hFGF10 + hFGFR2 <br /> | ||
*FGF12 | |||
[[1q1u]] – hFGF12 (mutant) <br /> | **[[1q1u]] – hFGF12 (mutant) <br /> | ||
*FGF13 | |||
[[3hbw]] – hFGF13 <br /> | **[[3hbw]] – hFGF13 <br /> | ||
[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br /> | **[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br /> | ||
*FGF19 | |||
[[1pwa]], [[2p23]] – hFGF19 <br /> | **[[1pwa]], [[2p23]] – hFGF19 <br /> | ||
*FGF20 | |||
[[3f1r]] – hFGF20 <br /> | **[[3f1r]] – hFGF20 <br /> | ||
*FGF23 | |||
[[2p39]] – hFGF23 <br /> | **[[2p39]] – hFGF23 <br /> | ||
}} | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:43, 25 November 2014
Fibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types.
- FGF1 is called acidic FGF.
- FGF2 is called basic FGF.
- FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound.
3D structures of fibroblast growth factor3D structures of fibroblast growth factor
Updated on 25-November-2014