Histone methyltransferase: Difference between revisions
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{{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | {{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | ||
'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. | '''Histone methyltransferase''' (HMT) are '''histone-lysine N-methyltransferase''' (KHMT) and '''histone-arginine N-methyltransferase''' (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. | ||
== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
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[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | [[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | ||
[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | [[2g46]] – PvKHMT + SAH + H3 peptide<br /> | ||
[[4au7]] - | [[4au7]] - mKHMT + SAH + H4 peptide - mouse<br /> | ||
===Histone-arginine N-methyltransferase (Carm1)=== | |||
[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | |||
[[2obq]] – rRHMT N terminal - rat <br /> | |||
[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | |||
[[3b3f]] – rRHMT catalytic domain + SAH<br /> | |||
[[2y1w]], [[2y1x]] – hRHMT catalytic domain + sinefungin + indole inhibitor<br /> | |||
[[4ikp]] – hRHMT catalytic domain + purine derivative<br /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||