Tissue factor: Difference between revisions
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<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor complex with coagulation factor VIIa heavy chain and light chain and | <StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor (dark green) complex with coagulation factor VIIa heavy chain (red) and light chain (aqua) and Ca+2 ion (green) (PDB code [[2aer]]).' scene=''> | ||
== Function == | == Function == | ||
Revision as of 13:47, 16 July 2014
<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor (dark green) complex with coagulation factor VIIa heavy chain (red) and light chain (aqua) and Ca+2 ion (green) (PDB code 2aer).' scene=>
FunctionFunction
Tissue factor (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade.
DiseaseDisease
RelevanceRelevance
Structural highlightsStructural highlights
3D structures of tissue factor3D structures of tissue factor
Updated on 16-July-2014
1a21 – rTF extracellular domain – rabbit
2hft, 1boy, 1tfh – hTF extracellular domain – human
Tissue factor binary complexTissue factor binary complex
1dan, 1j9c, 1w0y – hTF extracellular domain + factor VIIA
1o5d – hTF extracellular domain (mutant) + factor VIIA
1ahw, 1jps, 1uj3 – hTF extracellular domain + antibody
Tissue factor ternary complex with coagulation factor VIIa and inhibitorTissue factor ternary complex with coagulation factor VIIa and inhibitor
1fak – hTF extracellular domain + factor VIIA + BPTI
1z6j, 1w2k, 2b7d, 2f9b, 2flb, 2a2q, 2aer, 2fir, 2aei, 2c4f, 2flr, 2ec9, 2zp0, 2zzu, 3th2, 4ibl – hTF extracellular domain + factor VIIA + inhibitor
1wqv, 1wss, 1wtg, 1wun, 1wv7, 2b8o, 2puq, 3ela, 2zwl, 3th3, 3th4 – hTF extracellular domain + factor VIIA + peptide mimetic inhibitor