Exotoxin: Difference between revisions

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New page: <StructureSection load='3q9o' size='340' side='right' caption='Structure of ''Vibrio cholerae'' exotoxin complex with inhibitor (PDB code 3q9o).' scene=''> == Function == Exotoxins ...
 
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<StructureSection load='3q9o' size='340' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene=''>
<StructureSection load='3q9o' size='340' side='right' caption='Structure of ''Vibrio cholerae'' exotoxin complex with inhibitor (PDB code [[3q9o]]).' scene=''>


== Function ==
== Function ==
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[[2q5t]] – VcET <br />
[[2q5t]] – VcET <br />
[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
[[3q9o]] – VcET + inhibitor <br />
[[3q9o]] – VcET + NAD <br />


===''Streptococcus pyogenes'' exotoxin===
===''Streptococcus pyogenes'' exotoxin===

Revision as of 10:22, 25 June 2014

<StructureSection load='3q9o' size='340' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code 3q9o).' scene=>

FunctionFunction

Exotoxins (ET) are toxins which are secreted by bacteria.

DiseaseDisease

RelevanceRelevance

Structural highlightsStructural highlights

3D structures of exotoxin3D structures of exotoxin

Updated on 25-June-2014

Pseudomonas aeruginosa exotoxinPseudomonas aeruginosa exotoxin

1ikq – PaET A
1ikp – PaET A (mutant)
1dma – PaET A catalytic domain + nicotinamide + AMP
1aer – PaET A catalytic domain + NAD analog + AMP
1xk9 – PaET A catalytic domain + inhibitor
1zm2 – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2
1zm3 – PaET A catalytic domain + diphthamide + EF-2
3b78, 2zit – PaET A catalytic domain + diphthamide + NAD + EF-2
3b82, 3b8h – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2
1zm4 – PaET A catalytic domain + diphthamide + NAD analog + EF-2
1zm9 – PaET A catalytic domain + diphthamide + inhibitor + EF-2

Vibrio cholerae exotoxinVibrio cholerae exotoxin

2q5t – VcET
2q6m, 3ess, 3ki0, 3ki1, 3ki2, 3ki3, 3ki4, 3ki5, 3ki6, 3ki7, 3ny6 – VcET catalytic domain + inhibitor
3q9o – VcET + NAD

Streptococcus pyogenes exotoxinStreptococcus pyogenes exotoxin

1b1z, 1fnu, 1fnv, 1fnw – SpET A1
1dki – SpET B
2jtc – SpET B (mutant) - NMR
1an8 – SpET C
1et9 – SpET H
1ty0 – SpET J
1ha5, 1uup – SpET A1 + Zn
1l0x – SpET A1 (mutant) + T cell receptor β chain
1pvj – SpET B + inhibitor
2uzj – SpET B + guanidine derivative
1eu4 – SpET H + Zn
1ty2 – SpET J + Zn
1ktk – SpET C (mutant) + T cell receptor β chain
1l0y – SpET A1 (mutant) + T cell receptor β chain + Zn
1hqr – SpRT C + antibody + myelin basic protein

Staphylococcus aureus exotoxinStaphylococcus aureus exotoxin

1v1o, 1v1p – SaET 1
2r61, 2z8l – SaET 3
3o13 – SaET 15
3kls – SaET 1 (mutant) + complement C5

Corynebacterium diphtheriae exotoxinCorynebacterium diphtheriae exotoxin

See Diphtheria toxin




ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky