3v7o: Difference between revisions
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<StructureSection load='3v7o' size='340' side='right' caption='[[3v7o]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3v7o' size='340' side='right' caption='[[3v7o]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. <br> | <table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V7O FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [http://www.ebi.ac.uk/pdbsum/3v7o PDBsum]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/VP30_EBORR VP30_EBORR]] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref> | Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Nucleoprotein|Nucleoprotein]] | |||
*[[Transcriptional activator|Transcriptional activator]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Eborr]] | [[Category: Eborr]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Ebola]] | [[Category: Ebola]] | ||
[[Category: Nucleoprotein]] | [[Category: Nucleoprotein]] | ||
[[Category: Smt]] | [[Category: Smt]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Vp30]] | [[Category: Vp30]] | ||
Revision as of 09:52, 25 December 2014
Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)
Structural highlights
Function[VP30_EBORR] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). Publication Abstract from PubMedThe ebolaviruses can cause severe hemorrhagic fever. Essential to the ebolavirus life cycle is the protein VP30, which serves as a transcriptional cofactor. Here, the crystal structure of the C-terminal, NP-binding domain of VP30 from Reston ebolavirus is presented. Reston VP30 and Ebola VP30 both form homodimers, but the dimeric interfaces are rotated relative to each other, suggesting subtle inherent differences or flexibility in the dimeric interface. Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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