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==Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme==
==Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme==
<StructureSection load='4l4s' size='340' side='right' caption='[[4l4s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4l4s' size='340' side='right' caption='[[4l4s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==

Revision as of 09:58, 7 May 2014

Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozymeStructural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme

Structural highlights

4l4s is a 2 chain structure. Full crystallographic information is available from OCA.
Ligands:
Related:4l4r
Activity:Glucokinase, with EC number 2.7.1.2
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]

Function

References

  1. ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430

4l4s, resolution 2.90Å

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OCA
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