Histone methyltransferase: Difference between revisions

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{{STRUCTURE_3s7j|  PDB=3s7j  | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }}
{{STRUCTURE_3s7j|  PDB=3s7j  | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }}


'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT)  and histone-arginine N-methyltransferase (RHMT)  which catalyzes the transfer of methyl groups to lysine and arginine residues of histones.  HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.  KHMT can be SET domain-containing or non-SET domain-containing.  The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.
'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT)  and histone-arginine N-methyltransferase (RHMT)  which catalyzes the transfer of methyl groups to lysine and arginine residues of histones.  HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.  KHMT can be SET domain-containing or non-SET domain-containing.  The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.  CxxC domain is a zinc finger domain.


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[[3toj]] – hKHMT Ash2 Spry domain<br />
[[3toj]] – hKHMT Ash2 Spry domain<br />
[[4ijd]] – hKHMT Prdm9<br />
[[4ijd]] – hKHMT Prdm9<br />
[[4mi0]] – hKHMT Ezh2<br />
[[4mi5]] – hKHMT Ezh2 SET domain<br />
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
[[1u2z]] – yKHMT C terminal<br />
[[1u2z]] – yKHMT C terminal<br />
[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br />
[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br />
[[2l7p]] – AtKHMT Suvr4 SET31 - NMR<br />
[[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br />


===Histone-lysine N-methyltransferase binary complexes===
===Histone-lysine N-methyltransferase binary complexes===


[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
[[4nw3]] – hKHMT Mll CxxC domain + DNA <br />
[[4pzi]] – hKHMT CxxC domain + DNA <br />
[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
[[3qow]] – hKHMT + SAM <br />
[[3qow]] – hKHMT + SAM <br />
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[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
[[3rib]] – hKHMT Smyd2 + SAH<br />
[[3rib]] – hKHMT Smyd2 + SAH<br />
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
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[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />


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[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br />
[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br />
[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
[[4j7i]], [[4j83]], [[4j8o]] - hKHMT SETD7 + SAH + TFIID peptide<br />
[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br />
[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
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[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br />
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br />
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
[[1zkk]] - hKHMT + SAH + H4 peptide <br />
[[1zkk]] - hKHMT + SAH + H4 peptide <br />
[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />

Revision as of 11:20, 11 June 2014

Template:STRUCTURE 3s7j

Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain.

3D Structures of histone methyltransferase3D Structures of histone methyltransferase

Updated on 11-June-2014

1nw3 – hHMT DOT1L – human

2igq – hHMT-1 C terminal

Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase

2j8a – KHMT SET1 RRM domain – yeast

3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT SET7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
2kyu - hKHMT Mll Phd3 finger – NMR
4gnd - hKHMT Nsd3 Phd5-C5HCH
3lqh - hKHMT Mll Phd bromodomain
3b7b - hKHMT ankyrin repeat domains 2-7
3bo5 – hKHMT Setmar methyltransferase domain
3k9j, 3k9k – hKHMT Setmar transposable domain (mutant)
3dlm - hKHMT Setmdb1 Tudor domain
3n71 - hKHMT Smyd1
3rsn, 3s32 – hKHMT Ash2 N terminal
3toj – hKHMT Ash2 Spry domain
4ijd – hKHMT Prdm9
4mi0 – hKHMT Ezh2
4mi5 – hKHMT Ezh2 SET domain
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal
2l7p – AtKHMT Ashh2 CW domain – Arabidopsis thaliana - NMR
2lxe – AtKHMT Suvr4 SET31 - NMR

Histone-lysine N-methyltransferase binary complexesHistone-lysine N-methyltransferase binary complexes

2kkf – hKHMT Hrx CxxC domain +_DNA – NMR
4nw3 – hKHMT Mll CxxC domain + DNA
4pzi – hKHMT CxxC domain + DNA
3q0b, 3q0c, 3q0d, 3q0f – hKHMT SRA domain +_DNA
3qow – hKHMT + SAM
4fmu – hKHMT SETD2 + inhibitor
4h12 – hKHMT SETD2 + SAH
3smt – hKHMT SETD3 + SAM
4bup, 3ooi – hKHMT SET domain + SAM
3qox, 3sx0 – hKHMT + SAH
3sr4, 3uwp, 4ek9, 4ekg, 4eki, 4eqz, 4er0, 4er3, 4er5, 4er6, 4er7, 4hra - hKHMT catalytic domain + inhibitor
2w5y – hKHMT Hrx methyltransferase domain +_SAH
3lqi, 3lqj - hKHMT Mll Phd bromodomain + H3 peptide
3f2k – hKHMT Setmar SET domain + LYFA peptide
3sw9, 3swc – hKHMT SET domain + peptide
4gne, 4gnf, 4gng - hKHMT Nsd3 Phd5-C5HCH + H3 peptide
3b95 - hKHMT ankyrin repeat domain + H3 peptide
3lqi, 3lqj - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide
3rib – hKHMT Smyd2 + SAH
3s7j, 3tg4 - hKHMT Smyd2 + SAM
1mt6 - hKHMT SET7/9 residues 58-337 + SAH
1n6a – hKHMT SET7/9 SET domain + SAM
1n6c – hKHMT SET7/9 residues 70-366 + SAM
3cbp - hKHMT SET7/9 SET domain + sinefungin
3vuz, 3vv0 - hKHMT SET7/9 SET domain + deoxyadenosine derivative
4l58 - hKHMT PHD-type zinc finger domain + H3 peptide

Histone-lysine N-methyltransferase ternary complexHistone-lysine N-methyltransferase ternary complex

2w5z – hKHMT Hrx methyltransferase domain +_SAH + histone peptide
1o9s - hKHMT SET7/9 SET domain + SAH + H3 peptide
2bqz - hKHMT SET7 SET domain + SAH + H4 peptide
3f9w, 3f9x, 3f9y, 3f9z - hKHMT SETD8 SET domain + SAH + H4 peptide
4ij8 - hKHMT SETD8 + SAM + H3 peptide
4j7i, 4j83, 4j8o, 4j7f - hKHMT SETD7 + SAH + TFIID peptide
3fpd, 3k5k, 3mo0, 3mo2, 3mo5, 3rjw, 4nvq - hKHMT SET domain + SAH + inhibitor
2rfi, 3hna - hKHMT H3K9 catalytic domain + SAH + H3 peptide
1xqh - hKHMT SET7/9 SET domain + SAH + p53 peptide
2f69, 3m53 - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide
3m54, 3m55, 3m56, 3m57, 3m58, 3m59, 3m5a - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide
3cbm - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide
4e47, 4jds, 4jlg - hKHMT SET7/9 SET domain + SAM + inhibitor
3cbo - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide
3os5 - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide
3qxy, 3rc0 - hKHMT SETD6 SET domain + p65 peptide + SAM
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
4o6f – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide
1zkk - hKHMT + SAH + H4 peptide
4c1q - hKHMT SET domain + SAH + H3 peptide
4i51 - hKHMT (mutant) + SAH + H3 peptide
1peg - NcKHMT Dim-5 + SAH + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide
4au7 - KHMT + SAH + H4 peptide - mouse

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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