BAG protein: Difference between revisions
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<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene=''> | <StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene=''> | ||
The '''BAG family proteins ('''Bcl-2 associated athanogenes) perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. | The '''BAG family proteins ('''Bcl-2 associated athanogenes''') perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. | ||
==3D structures of BAG family proteins== | ==3D structures of BAG family proteins== | ||
Revision as of 14:50, 20 November 2013
<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry 3fzf)' scene=>
The BAG family proteins (Bcl-2 associated athanogenes) perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. BAG-1, BAG-2, BAG-4, BAG-5 or BAG family molecular chaperone regulator inhibit the chaperone function of HSC70 and have anti-apoptotic function.
3D structures of BAG family proteins3D structures of BAG family proteins
Updated on 20-November-2013
BAG-1
1i6z – mBAG-1 BAG domain - mouse
2lwp – mBAG-1 BAG domain - NMR
1t7s – BAG-1 BAG domain – Caenorhabditis elegans
4hwc – AtBAG-1 BAG domain – Arabidopsis thaliana
1wxv – hBAG-1 BAG domain – human - NMR
BAG-1 complex with HSC70
3fzf – hBAG-1 BAG domain + HSC70 ATPase domain + ATP
3fzh, 3fzk, 3fzl, 3fzm, 3ldq, 3m3z – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor
4hwi – AtBAG-1 BAG domain + HSC70 ATPase domain
1hx1 – BAG-1 BAG domain + HSC70 ATPase domain - bovine
BAG-2
3d0t – mBAG-2 BAG domain
BAG-2 complex with HSC70
3cqx – mBAG-2 BAG domain + HSC70 ATPase domain
BAG-4
1m62, 1m7k – hBAG-4 BAG domain - NMR
BAG-5
1ugo – mBAG-5 BAG domain - NMR
2d9d – hBAG-5 BAG domain - NMR
BAG-5 complex with HSC70
3a8y – hBAG-5 BAG domain + HSC70 ATPase domain