Ricin: Difference between revisions
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== Site of ricin modification of rRNA == | == Site of ricin modification of rRNA == | ||
<load='3u5d' size='400' side='left' caption='ribosomal RNA from Yeast(PDB entry [[3u5d]])' scene=''> | <Structure load='3u5d' size='400' side='left' caption='ribosomal RNA from Yeast(PDB entry [[3u5d]])' scene=''> | ||
Ricin removes an adenine from a specific portion of the 28S rRNA called the <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Sarcin-ricin_loop/1'>sacrin-ricin loop</scene>, or SRL. This <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Depurination/1'>depurination</scene> leads to reduced binding of elongation factors to the ribosome and reduced synthesis of proteins. It appears that binding of ricin chain A is mediated by binding to the ribosomal proteins and the ribosomal stalk, as binding to the naked rRNA occurs with lower affinity.<ref name="Chiou">PMID: 19019145</ref>. | Ricin removes an adenine from a specific portion of the 28S rRNA called the <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Sarcin-ricin_loop/1'>sacrin-ricin loop</scene>, or SRL. This <scene name='Taylor_sandboxk_ricin_rRNA_modification_site/Depurination/1'>depurination</scene> leads to reduced binding of elongation factors to the ribosome and reduced synthesis of proteins. It appears that binding of ricin chain A is mediated by binding to the ribosomal proteins and the ribosomal stalk, as binding to the naked rRNA occurs with lower affinity.<ref name="Chiou">PMID: 19019145</ref>. | ||
Ricin also triggers apoptosis <ref name="Tesh">PMID: 22130961</ref>, though the exact pathway is a current research topic. There is some evidence that it occurs via the B subunit <ref name="Yermakova">PMID: 22984492</ref>, though there is also evidence that the protein synthesis inhibition may cause apoptosis <ref name="Jetzt">PMID: 22982239</ref>. | |||