4enz: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4enz| PDB=4enz | SCENE= }} | {{STRUCTURE_4enz| PDB=4enz | SCENE= }} | ||
===Structure of human ceruloplasmin at 2.6 A resolution=== | ===Structure of human ceruloplasmin at 2.6 A resolution=== | ||
{{ABSTRACT_PUBMED_23843990}} | |||
==Disease== | ==Disease== | ||
| Line 10: | Line 11: | ||
==About this Structure== | ==About this Structure== | ||
[[4enz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENZ OCA]. | [[4enz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENZ OCA]. | ||
==See Also== | |||
*[[Ceruloplasmin|Ceruloplasmin]] | |||
==Reference== | |||
<ref group="xtra">PMID:023843990</ref><references group="xtra"/><references/> | |||
[[Category: Ferroxidase]] | [[Category: Ferroxidase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 07:06, 12 September 2013
Structure of human ceruloplasmin at 2.6 A resolutionStructure of human ceruloplasmin at 2.6 A resolution
Template:ABSTRACT PUBMED 23843990
DiseaseDisease
[CERU_HUMAN] Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
FunctionFunction
[CERU_HUMAN] Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
About this StructureAbout this Structure
4enz is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Samygina VR, Sokolov AV, Bourenkov G, Petoukhov MV, Pulina MO, Zakharova ET, Vasilyev VB, Bartunik H, Svergun DI. Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins. PLoS One. 2013 Jul 3;8(7):e67145. doi: 10.1371/journal.pone.0067145. Print 2013. PMID:23843990 doi:10.1371/journal.pone.0067145