Ceruloplasmin

Function Ceruloplasmin (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism. Relevance CP testing is used in diagnosis of the rare inherited disorder - Wilson disease. Disease CP mutation causes the autosomal recessive disorder - Aceruloplasminemia which results in accumulation of iron in the brain. Structural highlights and in human ceruloplasmin (PDB entry 1kcw).

spinqualitylabelsall models Glycosylated human ceruloplasmin complex with Cu+2 ions (orange) and O atoms (red) (PDB entry 1kcw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of ceruloplasmin3D structures of ceruloplasmin

Updated on 11-February-2019

1kcw, 2j5w, 4enz – hCP - human
4ejx – hCP + myeloperoxidase
5n0k, 5n4l – CP – rat