Histone methyltransferase: Difference between revisions
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{{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | {{STRUCTURE_3s7j| PDB=3s7j | SIZE=400| SCENE= |right|CAPTION=Human histone-lysine N-methyltrasferase Smyd2 complex with S-adenosyl methionine, [[3s7j]] }} | ||
'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. | '''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. | ||
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[[3rib]] – hKHMT Smyd2 + SAH<br /> | [[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
[[1o9s]] - hKHMT Set7/9 | [[1o9s]] - hKHMT Set7/9 Set domain + SAH + H3 peptide<br /> | ||
[[2bqz]] - hKHMT Set7 | [[2bqz]] - hKHMT Set7 Set domain + SAH + H4 peptide<br /> | ||
[[1mt6]] - hKHMT Set7/9 residues 58-337 + SAH<br /> | [[1mt6]] - hKHMT Set7/9 residues 58-337 + SAH<br /> | ||
[[ | [[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | ||
[[ | [[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br /> | ||
[[ | [[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br /> | ||
[[2f69]], [[3m53]] - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide<br /> | |||
[[3m54]], [[3m55]], [[3m56]], [[3m57]], [[3m58]], [[3m59]], [[3m5a]] - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide<br /> | |||
[[3cbm]] - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide<br /> | |||
[[4e47]], [[4jds]], [[4jlg]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br /> | |||
[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br /> | |||
[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br /> | |||
[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br /> | |||
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | |||
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | [[3s7b]] - hKHMT Smyd2 + SAM + inhibitor | ||
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[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | [[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
[[1peg]] - NcKHMT Dim-5 + H3 peptide<br /> | [[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | ||
[[2g46]] – PvKHMT + SAH + H3 peptide<br /> | [[2g46]] – PvKHMT + SAH + H3 peptide<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:49, 25 June 2013
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.
3D Structures of histone methyltransferase3D Structures of histone methyltransferase
Updated on 25-June-2013
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT Set7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
3n71 - hKHMT Smyd1
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal
Histone-lysine N-methyltransferase complexesHistone-lysine N-methyltransferase complexes
3rib – hKHMT Smyd2 + SAH
1o9s - hKHMT Set7/9 Set domain + SAH + H3 peptide
2bqz - hKHMT Set7 Set domain + SAH + H4 peptide
1mt6 - hKHMT Set7/9 residues 58-337 + SAH
1n6a – hKHMT SET7/9 SET domain + SAM
1n6c – hKHMT SET7/9 residues 70-366 + SAM
1xqh - hKHMT SET7/9 SET domain + SAH + p53 peptide
2f69, 3m53 - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide
3m54, 3m55, 3m56, 3m57, 3m58, 3m59, 3m5a - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide
3cbm - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide
4e47, 4jds, 4jlg - hKHMT SET7/9 SET domain + SAM + inhibitor
3cbo - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide
3os5 - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide
3cbp - hKHMT SET7/9 SET domain + sinefungin
3vuz, 3vv0 - hKHMT SET7/9 SET domain + deoxyadenosine derivative
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
3s7j, 3tg4 - hKHMT Smyd2 + SAM
1peg - NcKHMT Dim-5 + SAH + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide