Cell death protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 __NOTOC__
-'''Cell death proteins''' (CED) are involved in the process of cellular apoptosis.  For details on CED-4 see [[CED-4 Apoptosome]].
+'''Cell death proteins''' or '''Programmed cell death protein''' (CED) are involved in the process of cellular apoptosis.  CED-1 is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes.  For details on CED-4 see [[CED-4 Apoptosome]].
 ==3D structures of cell death protein==
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 ===CED-1===
-[[3rrq]] - hCED-1 extracellular domain – human<BR />
+[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
-[[3sbw]] - mCED-1 extracellular domain + CED ligand 1 – mouse<BR />
+[[3rrq] - hCED-1 extracellular domain (mutant) - human<br />
-[[3rnq]], [[3rnk]], [[3bp5]] - mCED-1 extracellular domain + CED ligand 2<BR />
+[[2m2d] - hCED-1 extracellular domain - NMR<br />
-[[3bp6]] - mCED-1 extracellular domain (mutant) + CED ligand 2<BR />
+[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
-[[1npu]] - mCED-1 extracellular domain (mutant) <BR />
+[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
-[[3bik]] - hCED-1 extracellular domain + CED ligand 1
+[[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br />
+[[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br />
+[[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br />
 ===CED-2===