4j1o: Difference between revisions

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[[Image:4j1o.jpg|left|200px]]
==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound l-proline betaine (substrate)==
 
<StructureSection load='4j1o' size='340' side='right' caption='[[4j1o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
{{STRUCTURE_4j1o|  PDB=4j1o  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4j1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans_pd1222 Paracoccus denitrificans pd1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1O FirstGlance]. <br>
===Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound l-proline betaine (substrate)===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PBE:1,1-DIMETHYL-PROLINIUM'>PBE</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1o RCSB], [http://www.ebi.ac.uk/pdbsum/4j1o PDBsum]</span></td></tr>
 
</table>
==About this Structure==
== Function ==
[[4j1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Paracoccus_denitrificans_pd1222 Paracoccus denitrificans pd1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1O OCA].  
[[http://www.uniprot.org/uniprot/A1B198_PARDP A1B198_PARDP]] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Paracoccus denitrificans pd1222]]
[[Category: Paracoccus denitrificans pd1222]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Bhosle, R.]]
[[Category: Bhosle, R]]
[[Category: Bonanno, J B.]]
[[Category: Bonanno, J B]]
[[Category: Chamala, S.]]
[[Category: Chamala, S]]
[[Category: Evans, B.]]
[[Category: Evans, B]]
[[Category: Gerlt, J A.]]
[[Category: Gerlt, J A]]
[[Category: Gizzi, A.]]
[[Category: Gizzi, A]]
[[Category: Hammonds, J.]]
[[Category: Hammonds, J]]
[[Category: Hillerich, B.]]
[[Category: Hillerich, B]]
[[Category: Kar, A.]]
[[Category: Kar, A]]
[[Category: LaFleur, J.]]
[[Category: LaFleur, J]]
[[Category: Love, J.]]
[[Category: Love, J]]
[[Category: Morisco, L L.]]
[[Category: Morisco, L L]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Structural genomic]]
[[Category: Seidel, R D.]]
[[Category: Seidel, R D]]
[[Category: Sojitra, S.]]
[[Category: Sojitra, S]]
[[Category: Stead, M.]]
[[Category: Stead, M]]
[[Category: Toro, R.]]
[[Category: Toro, R]]
[[Category: Vetting, M W.]]
[[Category: Vetting, M W]]
[[Category: Villigas, G.]]
[[Category: Villigas, G]]
[[Category: Wasserman, S R.]]
[[Category: Wasserman, S R]]
[[Category: Betaine racemase]]
[[Category: Betaine racemase]]
[[Category: Enolase]]
[[Category: Enolase]]
[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: New york structural genomics research consortium]]
[[Category: Nysgrc]]
[[Category: Nysgrc]]
[[Category: Proline betaine racemease]]
[[Category: Proline betaine racemease]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]

Revision as of 15:58, 4 January 2015

Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound l-proline betaine (substrate)Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound l-proline betaine (substrate)

Structural highlights

4j1o is a 2 chain structure with sequence from Paracoccus denitrificans pd1222. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[A1B198_PARDP] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.[1]

References

  1. ↑ Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP. Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature. 2013 Sep 22. doi: 10.1038/nature12576. PMID:24056934 doi:http://dx.doi.org/10.1038/nature12576

4j1o, resolution 1.60Å

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