2vr3: Difference between revisions
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{{STRUCTURE_2vr3| PDB=2vr3 | SCENE= }} | {{STRUCTURE_2vr3| PDB=2vr3 | SCENE= }} | ||
===STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF FIBRINOGEN BINDING TO CLFA FROM STAPHYLOCCCUS AUREUS=== | |||
{{ABSTRACT_PUBMED_19043557}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:[http://omim.org/entry/202400 202400]]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN]] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Fibrinogen|Fibrinogen]] | *[[Fibrinogen|Fibrinogen]] | ||
*[[Fibrinogen binding protein|Fibrinogen binding protein]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019043557</ref><references group="xtra"/> | <ref group="xtra">PMID:019043557</ref><references group="xtra"/><references/> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Bowden, M G.]] | [[Category: Bowden, M G.]] | ||
Revision as of 07:15, 25 March 2013
STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF FIBRINOGEN BINDING TO CLFA FROM STAPHYLOCCCUS AUREUSSTRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF FIBRINOGEN BINDING TO CLFA FROM STAPHYLOCCCUS AUREUS
Template:ABSTRACT PUBMED 19043557
DiseaseDisease
[FIBG_HUMAN] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
FunctionFunction
[FIBG_HUMAN] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
About this StructureAbout this Structure
2vr3 is a 4 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Ganesh VK, Rivera JJ, Smeds E, Ko YP, Bowden MG, Wann ER, Gurusiddappa S, Fitzgerald JR, Hook M. A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog. 2008 Nov;4(11):e1000226. Epub 2008 Nov 28. PMID:19043557 doi:10.1371/journal.ppat.1000226