1inc: Difference between revisions

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[[Image:1inc.png|left|200px]]
==CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS==
<StructureSection load='1inc' size='340' side='right' caption='[[1inc]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1inc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1INC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ICL:[1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC+ACID+TERT-BUTYL+ESTER'>ICL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1inc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1inc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1inc RCSB], [http://www.ebi.ac.uk/pdbsum/1inc PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/1inc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.


{{STRUCTURE_1inc|  PDB=1inc  |  SCENE=  }}
Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.,Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R J Mol Biol. 1987 Dec 5;198(3):417-24. PMID:3430613<ref>PMID:3430613</ref>


===CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_3430613}}
 
==About this Structure==
[[1inc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INC OCA].


==See Also==
==See Also==
*[[Elastase|Elastase]]
*[[Elastase|Elastase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:003430613</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Pancreatic elastase]]
[[Category: Pancreatic elastase]]
[[Category: Sus scrofa domesticus]]
[[Category: Sus scrofa domesticus]]
[[Category: Meyer, E.]]
[[Category: Meyer, E.]]

Revision as of 13:46, 3 October 2014

CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORSCRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS

Structural highlights

1inc is a 1 chain structure with sequence from Sus scrofa domesticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Pancreatic elastase, with EC number 3.4.21.36
Resources:FirstGlance, OCA, RCSB, PDBsum

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.

Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.,Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R J Mol Biol. 1987 Dec 5;198(3):417-24. PMID:3430613[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R. Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors. J Mol Biol. 1987 Dec 5;198(3):417-24. PMID:3430613

1inc, resolution 1.94Å

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