Elastase

Elastase (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. For additional details see Protease Serine Proteases. Relevance ELA1 in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. Disease Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. Structural highlights (cyan, green) complex with (magenta, yellow) (PDB code 1eai). ELA . 3D structures of elastase Elastase 3D structures

spinqualitylabelsall models Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image