Glyoxalase: Difference between revisions
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== | {{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I complex with glutathione derivative, [[1qin]] }} | ||
'''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione. GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]]. | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione. GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]]. | ||