2oxu: Difference between revisions

Revision as of 13:58, 27 July 2012

Ligands:

,

Gene:

MMP12, HME (Homo sapiens)

Activity:

Macrophage elastase, with EC number 3.4.24.65

Related:

1y93, 1rmz, 2oxw, 2oxz, 2oy2, 2oy4

Structural annotation:
Resources:	InterPro : Ipr000585, Ipr006025, Ipr002477, Ipr001818, Ipr006026 Pfam : PF00413 UniProt : P39900

Functional annotation:
Cellular component:	proteinaceous extracellular matrix
Biological process:	metabolic process proteolysis cell motility
Molecular function:	metallopeptidase activity catalytic activity metal ion binding macrophage elastase activity peptidase activity hydrolase activity metalloendopeptidase activity calcium ion binding zinc ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2oxu is a 1 chain structure of Elastase and Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

↑ Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ. Snapshots of the reaction mechanism of matrix metalloproteinases. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442 doi:10.1002/anie.200603100

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