Villin: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]] | [[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]] | ||
{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }} | {{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }} | ||
[[Villin]] (VIL) is an actin-binding protein. | [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin. '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). | ||
<br /> | <br /> | ||
Revision as of 14:34, 2 March 2011
Template:STRUCTURE 2k6n Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. [1] Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).
3D Structures of Villin3D Structures of Villin
SupervillinSupervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
VillinVillin
3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
AdvillinAdvillin
1und – hAVIL headpiece