3hc7: Difference between revisions

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[[Image:3hc7.jpg|left|200px]]


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==Crystal structure of lysin B from Mycobacteriophage D29==
The line below this paragraph, containing "STRUCTURE_3hc7", creates the "Structure Box" on the page.
<StructureSection load='3hc7' size='340' side='right'caption='[[3hc7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_virus_D29 Mycobacterium virus D29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HC7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc7 OCA], [https://pdbe.org/3hc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hc7 RCSB], [https://www.ebi.ac.uk/pdbsum/3hc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc7 ProSAT]</span></td></tr>
{{STRUCTURE_3hc7| PDB=3hc7 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSB_BPMD2 LYSB_BPMD2] Endolysin that degrades the junction between mycolic acid and peptidoglycans in the host cell wall and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the mycolic acid-rich outer membrane. Cleaves the ester linkage joining the mycolic acid-rich outer membrane to arabinogalactan, releasing free mycolic acids.<ref>PMID:19555454</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/3hc7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hc7 ConSurf].
<div style="clear:both"></div>


===Crystal structure of lysin B from Mycobacteriophage D29===
==See Also==
 
*[[Lysin 3D structures|Lysin 3D structures]]
 
== References ==
==About this Structure==
<references/>
3HC7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_phage_d29 Mycobacterium phage d29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC7 OCA].
__TOC__
[[Category: Mycobacterium phage d29]]
</StructureSection>
[[Category: Sacchettini, J C.]]
[[Category: Large Structures]]
[[Category: Sun, Q.]]
[[Category: Mycobacterium virus D29]]
[[Category: Alpha/beta sandwich]]
[[Category: Sacchettini JC]]
[[Category: Cell adhesion]]
[[Category: Sun Q]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:42:57 2009''

Latest revision as of 12:59, 21 February 2024

Crystal structure of lysin B from Mycobacteriophage D29Crystal structure of lysin B from Mycobacteriophage D29

Structural highlights

3hc7 is a 1 chain structure with sequence from Mycobacterium virus D29. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSB_BPMD2 Endolysin that degrades the junction between mycolic acid and peptidoglycans in the host cell wall and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the mycolic acid-rich outer membrane. Cleaves the ester linkage joining the mycolic acid-rich outer membrane to arabinogalactan, releasing free mycolic acids.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Payne K, Sun Q, Sacchettini J, Hatfull GF. Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase. Mol Microbiol. 2009 Aug;73(3):367-81. Epub 2009 Jun 22. PMID:19555454 doi:10.1111/j.1365-2958.2009.06775.x

3hc7, resolution 2.00Å

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