3hc7

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Crystal structure of lysin B from Mycobacteriophage D29Crystal structure of lysin B from Mycobacteriophage D29

Structural highlights

3hc7 is a 1 chain structure with sequence from Mycobacterium virus D29. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSB_BPMD2 Endolysin that degrades the junction between mycolic acid and peptidoglycans in the host cell wall and participates with the holin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the mycolic acid-rich outer membrane. Cleaves the ester linkage joining the mycolic acid-rich outer membrane to arabinogalactan, releasing free mycolic acids.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Payne K, Sun Q, Sacchettini J, Hatfull GF. Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase. Mol Microbiol. 2009 Aug;73(3):367-81. Epub 2009 Jun 22. PMID:19555454 doi:10.1111/j.1365-2958.2009.06775.x

3hc7, resolution 2.00Å

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OCA