1ft3: Difference between revisions

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[[Image:1ft3.png|left|200px]]


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==CRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANT==
The line below this paragraph, containing "STRUCTURE_1ft3", creates the "Structure Box" on the page.
<StructureSection load='1ft3' size='340' side='right'caption='[[1ft3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ft3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FT3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft3 OCA], [https://pdbe.org/1ft3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ft3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ft3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft3 ProSAT]</span></td></tr>
{{STRUCTURE_1ft3| PDB=1ft3 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/1ft3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ft3 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANT===
==See Also==
 
*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
 
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</StructureSection>
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{{ABSTRACT_PUBMED_11320308}}
 
==About this Structure==
1FT3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT3 OCA]. Relevant biological numbers for this protein at [http://bionumbers.hms.harvard.edu/search.aspx?log=y&task=searchbytrmorg&trm=%22immunoglobulin%22&org=%25 B10NUMB3R5]
 
==Reference==
<ref group="xtra">PMID:11320308</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Derewenda, Z S.]]
[[Category: Large Structures]]
[[Category: Garrard, S M.]]
[[Category: Derewenda ZS]]
[[Category: Longenecker, K L.]]
[[Category: Garrard SM]]
[[Category: Sheffield, P J.]]
[[Category: Longenecker KL]]
[[Category: Beta sandwich motif]]
[[Category: Sheffield PJ]]
[[Category: Gdp-dissociation inhibitor of rho gtpase]]
[[Category: Immunoglobulin fold]]
[[Category: Isoprenyl-binding domain]]
[[Category: Signaling protein inhibitor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon May 25 08:13:49 2009''

Latest revision as of 10:19, 7 February 2024

CRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANTCRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANT

Structural highlights

1ft3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GDIR1_HUMAN Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ft3, resolution 2.80Å

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