Guanine nucleotide dissociation inhibitor

Function Guanine nucleotide dissociation inhibitor or Rho GDP-dissociation inhibitor (GDI) bind to GDP-bound Rho (RhoGDI) and Rab small GTPase maintaining it in an off-stage and preventing the GTPase localization to the membrane. Relevance Levels of RhoGDI are significantly low in tumor tissues.

spinqualitylabelsall models Structure of mouse guanine nucleotide dissociation inhibitor (green) complex with GTPase RhoA (grey), geranyl geran, phosphoaminophosphonic acid-guanylate ester and Mg+2 ion (green) (PDB code 4f38). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of guanine nucleotide dissociation inhibitor3D structures of guanine nucleotide dissociation inhibitor

Updated on 25-April-2023

{"openlevels":0}

• RhoGDI
  • 1rho – hGDI1 (mutant) – human
    
  • 1fso, 1fst, 1ft0, 1ft3, 1kmt, 1qvy, 2bxw, 2jhs, 2jht, 2jhu, 2jhv, 2jhw, 2jhx, 2jhy, 2jhz, 2ji0 – hGDI1 C-terminal (mutant)
    
  • 5h1d – hGDI2
    
  • 1ajw, 1gdf – bGDI1 C-terminal – bovine - NMR
    
  • 1d5t, 1gnd – bGDI1
    
• RhoGDI complex
  • 1hh4 – hGDI1 + Ras-related C3 botulinum toxin substrate 1
    
  • 4f38 – mGDI1 + GTPase RhoA - mouse
    
  • 1cc0, 1doa – bGDI1 + GTPase RhoA
    
  • 5fr1, 5fr2 – bGDI1 + RhoA
    
  • 1lv0 – bGDI1 + geraylgeranyl peptide