1ef5: Difference between revisions

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-{{Seed}}
-[[Image:1ef5.png|left|200px]]
-<!--
+==SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL==
-The line below this paragraph, containing "STRUCTURE_1ef5", creates the "Structure Box" on the page.
+<StructureSection load='1ef5' size='340' side='right'caption='[[1ef5]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ef5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EF5 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ef5 OCA], [https://pdbe.org/1ef5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ef5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ef5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ef5 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ef5 TOPSAN]</span></td></tr>
-{{STRUCTURE_1ef5|  PDB=1ef5  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RGL1_MOUSE RGL1_MOUSE] Probable guanine nucleotide exchange factor.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1ef5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ef5 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
-===SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL===
+Solution structure of the Ras-binding domain of RGL.,Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:9891982<ref>PMID:9891982</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_9891982}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1ef5" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 9891982 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_9891982}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-EF5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA].
-==Reference==
-<ref group="xtra">PMID:9891982</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Endo, M.]]
+[[Category: Endo M]]
-[[Category: Ito, Y.]]
+[[Category: Ito Y]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Kikuchi, A.]]
+[[Category: Kikuchi A]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Ra]]
-[[Category: Ra]]
-[[Category: Ras-binding domain]]
-[[Category: Rbd]]
-[[Category: Rgl]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:08:21 2009''