3flv: Difference between revisions

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New page: '''Unreleased structure''' The entry 3flv is ON HOLD Authors: Ugochukwu, E., Roos, A., Yue, W.W., Shafqat, N., Savitsky, P., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H.,...
 
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'''Unreleased structure'''


The entry 3flv is ON HOLD
==The crystal structure of human acyl-CoenzymeA binding domain containing 5==
 
<StructureSection load='3flv' size='340' side='right'caption='[[3flv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
Authors: Ugochukwu, E., Roos, A., Yue, W.W., Shafqat, N., Savitsky, P., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3flv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FLV FirstGlance]. <br>
Description: The crystal structure of human acyl-CoenzymeA binding domain containing 5
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  7 09:35:44 2009''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3flv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flv OCA], [https://pdbe.org/3flv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3flv RCSB], [https://www.ebi.ac.uk/pdbsum/3flv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3flv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACBD5_HUMAN ACBD5_HUMAN] Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.<ref>PMID:24535825</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/3flv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3flv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards A]]
[[Category: Muniz JRC]]
[[Category: Oppermann U]]
[[Category: Roos A]]
[[Category: Salah E]]
[[Category: Savitsky P]]
[[Category: Shafqat N]]
[[Category: Ugochukwu E]]
[[Category: Weigelt J]]
[[Category: Yue WW]]
[[Category: Von Delft F]]

Latest revision as of 09:47, 6 September 2023

The crystal structure of human acyl-CoenzymeA binding domain containing 5The crystal structure of human acyl-CoenzymeA binding domain containing 5

Structural highlights

3flv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACBD5_HUMAN Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Nazarko TY, Ozeki K, Till A, Ramakrishnan G, Lotfi P, Yan M, Subramani S. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. J Cell Biol. 2014 Feb 17;204(4):541-57. doi: 10.1083/jcb.201307050. PMID:24535825 doi:http://dx.doi.org/10.1083/jcb.201307050

3flv, resolution 1.70Å

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