3flv

The crystal structure of human acyl-CoenzymeA binding domain containing 5The crystal structure of human acyl-CoenzymeA binding domain containing 5

Structural highlights

3flv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACBD5_HUMAN Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Nazarko TY, Ozeki K, Till A, Ramakrishnan G, Lotfi P, Yan M, Subramani S. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. J Cell Biol. 2014 Feb 17;204(4):541-57. doi: 10.1083/jcb.201307050. PMID:24535825 doi:http://dx.doi.org/10.1083/jcb.201307050

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OCA

[1] Nazarko TY, Ozeki K, Till A, Ramakrishnan G, Lotfi P, Yan M, Subramani S. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. J Cell Biol. 2014 Feb 17;204(4):541-57. doi: 10.1083/jcb.201307050. PMID:24535825 doi:http://dx.doi.org/10.1083/jcb.201307050

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