1vb7: Difference between revisions
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< | ==Solution structure of the PDZ domain of PDZ and LIM domain 2== | ||
<StructureSection load='1vb7' size='340' side='right'caption='[[1vb7]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1vb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VB7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vb7 OCA], [https://pdbe.org/1vb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vb7 RCSB], [https://www.ebi.ac.uk/pdbsum/1vb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vb7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1vb7 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDLI2_MOUSE PDLI2_MOUSE] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/1vb7_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vb7 ConSurf]. | |||
<div style="clear:both"></div> | |||
=== | ==See Also== | ||
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Hatta | [[Category: Hatta R]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | [[Category: Yoshida M]] | ||
[[Category: Yoshida | |||
Latest revision as of 03:00, 28 December 2023
Solution structure of the PDZ domain of PDZ and LIM domain 2Solution structure of the PDZ domain of PDZ and LIM domain 2
Structural highlights
FunctionPDLI2_MOUSE Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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