1jzz: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (12 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
< | ==Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria== | ||
<StructureSection load='1jzz' size='340' side='right'caption='[[1jzz]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1jzz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ROX:ROXITHROMYCIN'>ROX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzz OCA], [https://pdbe.org/1jzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzz RCSB], [https://www.ebi.ac.uk/pdbsum/1jzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RL4_DEIRA RL4_DEIRA] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).[HAMAP-Rule:MF_01328_B] Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.[HAMAP-Rule:MF_01328_B] This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.[HAMAP-Rule:MF_01328_B] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzz_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jzz ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Ribosomal protein L22|Ribosomal protein L22]] | |||
*[[Ribosomal protein L32|Ribosomal protein L32]] | |||
*[[Ribosomal protein L4|Ribosomal protein L4]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Deinococcus radiodurans]] | [[Category: Deinococcus radiodurans]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Albrecht | [[Category: Albrecht R]] | ||
[[Category: Bashan | [[Category: Bashan A]] | ||
[[Category: Franceschi | [[Category: Franceschi F]] | ||
[[Category: Harms | [[Category: Harms J]] | ||
[[Category: Schluenzen | [[Category: Schluenzen F]] | ||
[[Category: Tocilj | [[Category: Tocilj A]] | ||
[[Category: Yonath | [[Category: Yonath A]] | ||
[[Category: Zarivach | [[Category: Zarivach R]] | ||
Latest revision as of 10:43, 7 February 2024
Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in EubacteriaStructural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria
Structural highlights
FunctionRL4_DEIRA One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).[HAMAP-Rule:MF_01328_B] Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.[HAMAP-Rule:MF_01328_B] This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.[HAMAP-Rule:MF_01328_B] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
| ||||||||||||||||||