1q7t: Difference between revisions

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[[Image:1q7t.png|left|200px]]


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==Rv1170 (MshB) from Mycobacterium tuberculosis==
The line below this paragraph, containing "STRUCTURE_1q7t", creates the "Structure Box" on the page.
<StructureSection load='1q7t' size='340' side='right'caption='[[1q7t]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1q7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1q7t|  PDB=1q7t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7t OCA], [https://pdbe.org/1q7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7t RCSB], [https://www.ebi.ac.uk/pdbsum/1q7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7t ProSAT], [https://www.topsan.org/Proteins/TBSGC/1q7t TOPSAN]</span></td></tr>
 
</table>
===Rv1170 (MshB) from Mycobacterium tuberculosis===
== Function ==
 
[https://www.uniprot.org/uniprot/MSHB_MYCTU MSHB_MYCTU] Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol (MSH) biosynthesis pathway. Shows some amidase activity toward S-conjugates of mycothiol.<ref>PMID:11092856</ref>
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7t_consurf.spt"</scriptWhenChecked>
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==About this Structure==
  </jmolCheckbox>
1Q7T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7T OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7t ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis., McCarthy AA, Peterson NA, Knijff R, Baker EN, J Mol Biol. 2004 Jan 23;335(4):1131-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14698305 14698305]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Baker EN]]
[[Category: Baker, E N.]]
[[Category: Knijff R]]
[[Category: Knijff, R.]]
[[Category: McCarthy AA]]
[[Category: McCarthy, A A.]]
[[Category: Peterson NA]]
[[Category: Peterson, N A.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Modified rossmann fold]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:56:26 2008''

Latest revision as of 11:13, 14 February 2024

Rv1170 (MshB) from Mycobacterium tuberculosisRv1170 (MshB) from Mycobacterium tuberculosis

Structural highlights

1q7t is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MSHB_MYCTU Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol (MSH) biosynthesis pathway. Shows some amidase activity toward S-conjugates of mycothiol.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Newton GL, Av-Gay Y, Fahey RC. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J Bacteriol. 2000 Dec;182(24):6958-63. PMID:11092856

1q7t, resolution 1.90Å

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