1u5t: Difference between revisions

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[[Image:1u5t.png|left|200px]]


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==Structure of the ESCRT-II endosomal trafficking complex==
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<StructureSection load='1u5t' size='340' side='right'caption='[[1u5t]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1u5t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5t OCA], [https://pdbe.org/1u5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5t RCSB], [https://www.ebi.ac.uk/pdbsum/1u5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5t ProSAT]</span></td></tr>
{{STRUCTURE_1u5t|  PDB=1u5t  |  SCENE=  }}
</table>
 
== Function ==
===Structure of the ESCRT-II endosomal trafficking complex===
[https://www.uniprot.org/uniprot/SNF8_YEAST SNF8_YEAST] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5t ConSurf].
1U5T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5T OCA].  
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__TOC__
==Reference==
</StructureSection>
Structure of the ESCRT-II endosomal trafficking complex., Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH, Nature. 2004 Sep 9;431(7005):221-5. Epub 2004 Aug 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15329733 15329733]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Emr, S D.]]
[[Category: Emr SD]]
[[Category: Hierro, A.]]
[[Category: Hierro A]]
[[Category: Hurley, J H.]]
[[Category: Hurley JH]]
[[Category: Kim, J.]]
[[Category: Kim J]]
[[Category: Prag, G.]]
[[Category: Prag G]]
[[Category: Rusnak, A S.]]
[[Category: Rusnak AS]]
[[Category: Sun, J.]]
[[Category: Sun J]]
[[Category: Endosomal]]
[[Category: Escrt]]
[[Category: Protein complex]]
[[Category: Trafficking]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:56:48 2008''

Latest revision as of 11:44, 14 February 2024

Structure of the ESCRT-II endosomal trafficking complexStructure of the ESCRT-II endosomal trafficking complex

Structural highlights

1u5t is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNF8_YEAST Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1u5t, resolution 3.60Å

Drag the structure with the mouse to rotate

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OCA
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