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New page: left|200px<br /> <applet load="1ati" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ati, resolution 2.75Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1ati.gif|left|200px]]<br />
<applet load="1ati" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ati, resolution 2.75&Aring;" />
'''CRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS'''<br />


==Overview==
==CRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS==
The sequence and crystal structure at 2.75 A resolution of the homodimeric, glycyl-tRNA synthetase from Thermus thermophilus, the first representative, of the last unknown class II synthetase subgroup, have been determined., The three class II synthetase sequence motifs are present but the, structure was essential for identification of motif 1, which does not, possess the proline previously believed to be an essential class II, invariant. Nevertheless, crucial contacts with the active site of the, other monomer involving motif 1 are conserved and a more comprehensive, description of class II now becomes possible. Each monomer consists of an, active site strongly resembling that of the aspartyl and seryl enzymes, a, C-terminal anticodon recognition domain of 100 residues and a third ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7556056 (full description)]]
<StructureSection load='1ati' size='340' side='right'caption='[[1ati]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ati]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ATI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ati FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ati OCA], [https://pdbe.org/1ati PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ati RCSB], [https://www.ebi.ac.uk/pdbsum/1ati PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ati ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYG_THET8 SYG_THET8] Catalyzes the attachment of glycine to tRNA(Gly) (By similarity).[HAMAP-Rule:MF_00253_B]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/1ati_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ati ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1ATI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.14 6.1.1.14]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ATI OCA]].
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus., Logan DT, Mazauric MH, Kern D, Moras D, EMBO J. 1995 Sep 1;14(17):4156-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7556056 7556056]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Thermus thermophilus HB8]]
[[Category: Thermus thermophilus]]
[[Category: Kern D]]
[[Category: Kern, D.]]
[[Category: Logan DT]]
[[Category: Logan, D.T.]]
[[Category: Mazauric M-H]]
[[Category: Mazauric, M.H.]]
[[Category: Moras D]]
[[Category: Moras, D.]]
[[Category: aminoacyl-trna synthetase]]
[[Category: ligase]]
[[Category: protein biosynthesis]]
[[Category: synthetase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:00:56 2007''

Latest revision as of 09:33, 7 February 2024

CRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUSCRYSTAL STRUCTURE OF GLYCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS

Structural highlights

1ati is a 4 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYG_THET8 Catalyzes the attachment of glycine to tRNA(Gly) (By similarity).[HAMAP-Rule:MF_00253_B]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ati, resolution 2.75Å

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