1gnd: Difference between revisions

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New page: left|200px<br /><applet load="1gnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gnd, resolution 1.81Å" /> '''GUANINE NUCLEOTIDE D...
 
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[[Image:1gnd.gif|left|200px]]<br /><applet load="1gnd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1gnd, resolution 1.81&Aring;" />
'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''<br />


==Overview==
==GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM==
The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation, inhibitor (GDI), which functions in vesicle-membrane transport to recycle, and regulate Rab GTPases, has been determined to a resolution of 1.81 A., GDI is constructed of two main structural units, a large complex, multisheet domain I and a smaller alpha-helical domain II. The structural, organization of domain I is surprisingly closely related to FAD-containing, monooxygenases and oxidases. Sequence-conserved regions common to GDI and, the choroideraemia gene product, which delivers Rab to catalytic subunits, of Rab geranylgeranyltransferase II, are clustered on one face of the, molecule. The two most sequence-conserved regions, which form a compact, structure at the apex of GDI, are shown by site-directed mutagenesis to, play a critical role in the binding of Rab proteins.
<StructureSection load='1gnd' size='340' side='right'caption='[[1gnd]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GND FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnd OCA], [https://pdbe.org/1gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnd RCSB], [https://www.ebi.ac.uk/pdbsum/1gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GDIA_BOVIN GDIA_BOVIN] Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gnd ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1GND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA].
*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
 
__TOC__
==Reference==
</StructureSection>
Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8609986 8609986]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Balch, W.E.]]
[[Category: Balch WE]]
[[Category: Huang, M.]]
[[Category: Huang M]]
[[Category: Metteson, J.]]
[[Category: Metteson J]]
[[Category: Schalk, I.]]
[[Category: Schalk I]]
[[Category: Stura, E.A.]]
[[Category: Stura EA]]
[[Category: Tandon, A.]]
[[Category: Tandon A]]
[[Category: Wilson, I.A.]]
[[Category: Wilson IA]]
[[Category: Wu, S.K.]]
[[Category: Wu S-K]]
[[Category: Zeng, K.]]
[[Category: Zeng K]]
[[Category: gtpase activation]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:11:03 2007''

Latest revision as of 10:25, 7 February 2024

GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORMGUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM

Structural highlights

1gnd is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.81Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GDIA_BOVIN Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1gnd, resolution 1.81Å

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