3bpv: Difference between revisions

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==Crystal Structure of MarR==
The line below this paragraph, containing "STRUCTURE_3bpv", creates the "Structure Box" on the page.
<StructureSection load='3bpv' size='340' side='right'caption='[[3bpv]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_marburgensis_str._Marburg Methanothermobacter marburgensis str. Marburg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BPV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bpv OCA], [https://pdbe.org/3bpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bpv RCSB], [https://www.ebi.ac.uk/pdbsum/3bpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bpv ProSAT]</span></td></tr>
{{STRUCTURE_3bpv|  PDB=3bpv |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/O26413_METTH O26413_METTH]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bpv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bpv ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of MarR'''
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Transcriptional regulators belonging to the MarR family are characterized by a winged-helix DNA binding domain. These transcriptional regulators regulate the efflux and influx of phenolic agents in bacteria and archaea. In Escherichia coli, MarR regulates the multiple antibiotic resistance operon and its inactivation produces a multiple antibiotic resistance phenotype. In some organisms, active efflux of drug compounds will produce a drug resistance phenotype, whereas in other organisms, active influx of chlorinated hydrocarbons results in their rapid degradation. Although proteins in the MarR family are regulators of important biological processes, their mechanism of action is not well understood and structural information about how phenolic agents regulate the activity of these proteins is lacking. This article presents the three-dimensional structure of a protein of the MarR family, MTH313, in its apo form and in complex with salicylate, a known inactivator. A comparison of these two structures indicates that the mechanism of regulation involves a large conformational change in the DNA binding lobe. Electrophoretic mobility shift assay and biophysical analyses further suggest that salicylate inactivates MTH313 and prevents it from binding to its promoter region.
[[Category: Large Structures]]
 
[[Category: Methanothermobacter marburgensis str. Marburg]]
==About this Structure==
[[Category: Christendat D]]
3BPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BPV OCA].
[[Category: Saridakis V]]
 
[[Category: Shahinas D]]
==Reference==
[[Category: Xu X]]
Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum., Saridakis V, Shahinas D, Xu X, Christendat D, J Mol Biol. 2008 Mar 28;377(3):655-67. Epub 2008 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18272181 18272181]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Single protein]]
[[Category: Christendat, D.]]
[[Category: Saridakis, V.]]
[[Category: Shahinas, D.]]
[[Category: Xu, X.]]
[[Category: Dna binding]]
[[Category: Dna-binding]]
[[Category: Marr]]
[[Category: Transcription factor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator]]
[[Category: Winged helix motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:51:14 2008''

Latest revision as of 12:30, 21 February 2024

Crystal Structure of MarRCrystal Structure of MarR

Structural highlights

3bpv is a 1 chain structure with sequence from Methanothermobacter marburgensis str. Marburg. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O26413_METTH

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3bpv, resolution 1.40Å

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